Ultrasound has been a part of clinical practice since sometime back in the 1950's, and remains a popular and evidenced intervention for a range of clinical problems. Shah and Farrow (2012) provide an insight into its current clinical popularity as does the widely cited paper by Pope et al (1995). General (textbook) reviews and explanations can be found in Watson and Young (2008) and Robertson et al (2006) amongst others.
There are myriad therapy ultrasound machines available, from the small, portable devices, through to the multimodal machines which include ultrasound as one of the available options, examples are illustrated below.
ULTRASOUND ENERGY
Ultrasound (US) is a form of MECHANICAL energy, not electrical energy and therefore strictly speaking, not really electrotherapy at all but does fall into the Electro Physical Agents grouping. Mechanical vibration at increasing frequencies is known as sound energy. The normal human sound range is from 16Hz to something approaching 15-20,000 Hz (in children and young adults). Beyond this upper limit, the mechanical vibration is known as ULTRASOUND. The frequencies used in therapy are typically between 1.0 and 3.0 MHz (1MHz = 1 million cycles per second).








Sound waves are LONGITUDINAL waves consisting of areas of COMPRESSION and RAREFACTION. Particles of a material, when exposed to a sound wave will oscillate about a fixed point rather than move with the wave itself. As the energy within the sound wave is passed to the material, it will cause oscillation of the particles of that material. Clearly any increase in the molecular vibration in the tissue can result in heat generation, and ultrasound can be used to produce thermal changes in the tissues, though current usage in therapy does not focus on this phenomenon (Williams 1987, Baker et al 2001, ter Haar 1999, Nussbaum 1997, Watson 2000, 2008). In addition to thermal changes, the vibration of the tissues appears to have effects which are generally considered to be non thermal in nature, though, as with other modalities (e.g. Pulsed Shortwave) there must be a thermal component however small. As the US wave passes through a material (the tissues), the energy levels within the wave will diminish as energy is transferred to the material. The energy absorption and attenuation characteristics of US waves have been documented for different tissues (see absorption section).

THERAPEUTIC ULTRASOUND THERMAL AND NON THERMAL EFFECTS OVERVIEW
One of the therapeutic effects for which ultrasound has been used is in relation to tissue healing. It is suggested that the application of US to injured tissues will, amongst other things, speed the rate of healing & enhance the quality of the repair (Watson 2006). The following information is intended to provide a summary of some of the essential research in this field together with some possible mechanisms through which US treatments may achieve these changes. It is not intended to be a complete explanation of these phenomena or a comprehensive review of the current literature. It may, none the less, provide some useful basic information for clinical application. Some of the 'wider' applications for ultrasound therapy (e.g. drug delivery, chemotherapy potentiation) are usefully reviewed in Paliwal and Mitragotri (2008).
The therapeutic effects of US are generally divided into: THERMAL & NON-THERMAL.
THERMAL:
In thermal mode, US will be most effective in heating the dense collagenous tissues and will require a relatively high intensity, preferably in continuous mode to achieve this effect.
Many papers have concentrated on the thermal effectiveness of ultrasound, and much as it can be used effectively in this way when an appropriate dose is selected (continuous mode >0.5 W cm-2), the focus of this paper will be on the non thermal effects. Both Nussbaum (1998) and ter Haar (1999) have provided some useful review material with regards the thermal effects of ultrasound. Comparative studies on the thermal effects of ultrasound have been reported by several authors (e.g. Draper et al 1993, 1995a,b, Leonard et al 2004) with some interesting, and potentially useful results. Further work continues in our research centre with a comparison of contact heating and longwave ultrasound (Meakins and Watson, 2006) and comparison of different US regimes combined with US (Aldridge and Watson – in preparation)
It is too simplistic to assume that with a particular treatment application there will either be thermal or non thermal effects. It is almost inevitable that both will occur, but it is furthermore reasonable to argue that the dominant effect will be influenced by treatment parameters, especially the mode of application i.e. pulsed or continuous. Baker et al (2001) have argued the scientific basis for this issue coherently.
Lehmann (1982) suggests that the desirable effects of therapeutic heat can be produced by US. It can be used to selectively raise the temperature of particular tissues due to its mode of action. Among the more effectively heated tissues are periosteum, collagenous tissues (ligament, tendon & fascia) & fibrotic muscle (Dyson 1981). If the temperature of the damaged tissues is raised to 40-45°C, then a hyperaemia will result, the effect of which will be therapeutic. In addition, temperatures in this range are also thought to help in initiating the resolution of chronic inflammatory states (Dyson & Suckling 1978). Most authorities currently attribute a greater importance to the non-thermal effects of US as a result of several investigative trials in the last 15 years or so.
NON-THERMAL:
The non-thermal effects of US are now attributed primarily to a combination of CAVITATION and ACOUSTIC STREAMING (ter Haar 1999, 2008 Baker et al 2001, Williams 1987). There appears to be little by way of convincing evidence to support the notion of MICROMASSAGE though it does sound rather appealing.
CAVITATION in its simplest sense relates to the formation of gas filled voids within the tissues & body fluids. There are 2 types of cavitation - STABLE & UNSTABLE which have very different effects. STABLE CAVITATION does seem to occur at therapeutic doses of US. This is the formation & growth of gas bubbles by accumulation of dissolved gas in the medium. They take apx. 1000 cycles to reach their maximum size.

Therapeutic Ultrasound © Tim Watson 2013 Page 7
`cavity' acts to enhance the acoustic streaming phenomena (see below) & as such would appear to be beneficial. UNSTABLE (TRANSIENT) CAVITATION is the formation of bubbles at the low pressure part of the US cycle. These bubbles then collapse very quickly releasing a large amount of energy which is detrimental to tissue viability. There is no evidence at present to suggest that this phenomenon occurs at therapeutic levels if a good technique is used. There are applications of US that deliberately employ the unstable cavitation effect (High Intensity Focussed Ultrasound or HIFU) but it is beyond the remit of this summary.
ACOUSTIC STREAMING is described as a small scale eddying of fluids near a vibrating structure such as cell membranes & the surface of stable cavitation gas bubble (Dyson & Suckling 1978). This phenomenon is known to affect diffusion rates & membrane permeability. Sodium ion permeability is altered resulting in changes in the cell membrane potential. Calcium ion transport is modified which in turn leads to an alteration in the enzyme control mechanisms of various metabolic processes, especially concerning protein synthesis & cellular secretions.


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